GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs2294008 | 1 | rs2572910 | chr8:143770135 | PSCA | chr8:143761875-143764142:+ | 0.41 | 5.07 | 1.15E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs2585179 | chr8:143774193 | PSCA | chr8:143761875-143764142:+ | 0.41 | 4.96 | 1.83E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2602836 | 1 | rs2602836 | chr4:100014805 | ADH4 | chr4:100044835-100065449:- | 0.36 | 5.06 | 1.18E-6 | HDL cholesterol |
| UCEC | cis | rs9815354 | 1 | rs2625667 | chr3:41900951 | ULK4 | chr3:41288091-42003660:- | 0.52 | 6.25 | 3.94E-9 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs2625668 | chr3:41905930 | ULK4 | chr3:41288091-42003660:- | 0.53 | 6.52 | 9.73E-10 | Diastolic blood pressure |
| UCEC | cis | rs30187 | 1 | rs26510 | chr5:96125910 | ERAP1 | chr5:96096515-96149837:- | -0.44 | -5.32 | 3.7E-7 | Ankylosing spondylitis |
| UCEC | cis | rs9815354 | 1 | rs2683695 | chr3:41914928 | ULK4 | chr3:41288091-42003660:- | 0.53 | 6.52 | 9.73E-10 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs2683696 | chr3:41914898 | ULK4 | chr3:41288091-42003660:- | 0.55 | 6.64 | 5.2E-10 | Diastolic blood pressure |
| UCEC | cis | rs30187 | 1 | rs27529 | chr5:96126308 | ERAP1 | chr5:96096515-96149837:- | -0.4 | -4.76 | 4.56E-6 | Ankylosing spondylitis |
| UCEC | cis | rs30187 | 1 | rs27710 | chr5:96126197 | ERAP1 | chr5:96096515-96149837:- | 0.42 | 5.05 | 1.25E-6 | Ankylosing spondylitis |
| UCEC | cis | rs1577917 | 1 | rs2812972 | chr6:86669880 | SNHG5 | chr6:86386726-86388451:- | -0.46 | -5.96 | 1.65E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs2816815 | chr6:86691656 | SNHG5 | chr6:86386726-86388451:- | -0.44 | -5.79 | 3.91E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs2816821 | chr6:86657084 | SNHG5 | chr6:86386726-86388451:- | -0.46 | -5.98 | 1.51E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs3790645 | 1 | rs282176 | chr1:26898956 | ZNF593 | chr1:26496388-26497362:+ | -0.21 | -4.41 | 1.93E-5 | Glucose homeostasis traits |
| UCEC | cis | rs2839186 | 1 | rs2839186 | chr21:47690068 | C21orf57 | chr21:47706267-47717664:+ | -0.29 | -4.47 | 1.54E-5 | Testicular germ cell tumor |